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    Women

    Osteoporosis is the main cause of bone fractures in the elderly, and it causes pain, deformity, and disability. A recent study suggests that high blood pressure (hypertension) may contribute to the loss of bone in osteoporosis, by altering the way the body uses calcium.

    Researchers from the London School of Hygiene and Tropical Medicine, St. George's Hospital Medical School in London, and the University of Pittsburgh in Pennsylvania studied 3,676 white American women, 66 to 91 years old, who were participating in a long-term study.

    Knowing that hypertension seems to cause abnormal metabolism of calcium and loss of calcium from bones, they wanted to see if women with hypertension lost more bone. The women had x-rays of their femur bone taken twice, three and one-half years apart.

    The women were generally healthy. More than 15 percent took estrogen replacement therapy, and at the time of the second x-ray almost 17 percent were taking blood pressure medication. Few were smokers.

    Overall, the women lost about 0.5 percent of bone a year. Women who started the study with high blood pressure lost more bone and a higher percentage of bone, than those with normal blood pressure. And, the higher the blood pressure, the greater the bone loss. Smokers also had more bone loss, and women taking hormones had less, as was expected.

    Writing in journal "The Lancet," the authors concluded that "systolic blood pressure is a significant predictor of bone-mineral loss" in the femur. Their analysis indicates that this bone loss is not caused by age, body weight, weight changes, smoking, or medications.

    The researchers concluded that the effects of hypertension on calcium metabolism were probably responsible for the bone loss, but scientists don't yet know why high blood pressure does this. They pointed out that all the accepted ways of controlling hypertension-quitting smoking, exercising, and especially reducing salt intake-would probably help prevent bone loss too. High salt intake not only contributes to high blood pressure, but it also affects calcium balance, so avoiding salt is particularly important for women.


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